Poison Rune - December 2025
A brand new rune added in the latest update! Apply deadly poison damage over time to your enemies.
Rune ProfilePoison Rune Epic Rarity NEWThe Poison rune stacks with other poison effects. Combine with Venom Crumb or Rot Stitch for maximum poison damage!Stat Overview - PoisonPoison DamageVery HighStack PotentialHighDurationLong
How to Obtain
- Dropped by the new Blight Pyromancer enemy
- Crafted using Venom Crumb materials
- Found in poison-themed areas and dungeons
- Purchased from certain NPC vendors
Related Runes
Related Guides
Overview
The Poison Rune is a new rune added in the December 2025 update. It applies poison damage over time (DoT) to enemies hit by your attacks. This rune is perfect for players who prefer a damage-over-time playstyle, allowing you to stack poison on multiple enemies while kiting.
How to Obtain
Dropped by the new Blight Pyromancer enemy or crafted using Venom Crumb materials.
Usage Strategy
The Poison rune excels in prolonged fights where the DoT can stack up. Best paired with fast-attacking weapons like daggers or dual-wield setups to apply poison quickly. The poison effect stacks, so hitting an enemy multiple times increases the damage they take over time.
Pro Tips
The new VFX for runes (also added in this update) makes the Poison rune's effect more visible - you'll see a green toxic aura on poisoned enemies. This helps track which enemies are already poisoned so you can focus on spreading it to others.
Last Updated: December 10, 2025