NEW Poison
Poison rune in The Forge
Info
Type Rune
Element Poison
Rarity Epic
Added December 2025
Drop Sources
Primary Blight Pyromancer
Craft Venom Crumb

A newly discovered toxic essence that courses with deadly venom. Enemies touched by this poison find their strength sapped away as the toxin spreads through their veins.

NEW RUNE

Poison Rune - December 2025

A brand new rune added in the latest update! Apply deadly poison damage over time to your enemies.

Overview
The Poison rune applies poison damage over time (DoT) to enemies hit by your attacks. This rune is perfect for players who prefer a damage-over-time playstyle, allowing you to stack poison on multiple enemies while kiting.
Rune Profile
Poison Rune Epic Rarity NEW
The Poison rune stacks with other poison effects. Combine with Venom Crumb or Rot Stitch for maximum poison damage!
Stat Overview - Poison
Poison DamageVery High
Stack PotentialHigh
DurationLong

How to Obtain

  • Dropped by the new Blight Pyromancer enemy
  • Crafted using Venom Crumb materials
  • Found in poison-themed areas and dungeons
  • Purchased from certain NPC vendors

Related Runes

Related Guides

Overview

The Poison Rune is a new rune added in the December 2025 update. It applies poison damage over time (DoT) to enemies hit by your attacks. This rune is perfect for players who prefer a damage-over-time playstyle, allowing you to stack poison on multiple enemies while kiting.

How to Obtain

Dropped by the new Blight Pyromancer enemy or crafted using Venom Crumb materials.

Usage Strategy

The Poison rune excels in prolonged fights where the DoT can stack up. Best paired with fast-attacking weapons like daggers or dual-wield setups to apply poison quickly. The poison effect stacks, so hitting an enemy multiple times increases the damage they take over time.

Pro Tips

The new VFX for runes (also added in this update) makes the Poison rune's effect more visible - you'll see a green toxic aura on poisoned enemies. This helps track which enemies are already poisoned so you can focus on spreading it to others.

Last Updated: December 10, 2025